N,N-二甲基甲酰胺 → 四氢吡喃-4-乙酰氯

HRID 38787

反应方程式

HRID 38787 反应方程式
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([OH:10])=O)[CH2:3][CH2:2]1.CN(C)C=O.C(Cl)(=O)C([Cl:19])=O>ClCCl>[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([Cl:19])=[O:10])[CH2:3][CH2:2]1

参与物

5

反应物 3

HCID 6228N,N-二甲基甲酰胺HCID 65578草酰氯HCID 2773575四氢吡喃-4-乙酸

产物 1

HCID 24229747四氢吡喃-4-乙酰氯

试剂、催化剂与溶剂 1

HCID 6344二氯甲烷溶剂

实验过程

To a mixture of tetrahydro-2H-pyran-4-ylacetic acid (89 mg), N,N-dimethyl formamide (1 μL), and dichloromethane (1 mL) was added oxalylchloride (54 μL), and the mixture was stirred at room temperature for 2 hours. The reaction liquid was concentrated under reduced pressure, and then toluene (1 mL) was added thereto, followed by further concentration under reduced pressure, to obtain crude tetrahydro-2H-pyran-4-yl acetyl chloride.

后处理

  1. customThe reaction liquid
  2. concentrationwas concentrated under reduced pressure
  3. additiontoluene (1 mL) was added
  4. concentrationfollowed by further concentration under reduced pressure

来源与证据

ORD记录
ord-555ce1cf5e494e17afab4008bd8bce25
来源数据集
uspto-grants-2013_09
专利号
US08524727B2

关联笔记

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