1-(2-吡啶-2-基乙基)哌嗪 → 2-[4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-1-yl]-N,N-dimethyl-acetamide

HRID 390874

反应方程式

HRID 390874 反应方程式
[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH:11]=O)=[CH:8][C:6]=2[N:7]=1.[CH3:19][N:20]([CH3:30])[C:21](=[O:29])[CH2:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH2:11][N:26]3[CH2:25][CH2:24][N:23]([CH2:22][C:21]([N:20]([CH3:30])[CH3:19])=[O:29])[CH2:28][CH2:27]3)=[CH:8][C:6]=2[N:7]=1

参与物

3

反应物 2

HCID 27586421-(2-吡啶-2-基乙基)哌嗪HCID 457899852-氯-4-(4-吗啉)-噻吩并[3,2-D]嘧啶-6-羧醛

产物 1

HCID 574939702-[4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-1-yl]-N,N-dimethyl-acetamide

实验过程

Reaction between 2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde 10 (Example 3) and N,N-dimethyl-2-piperazin-1-yl-acetamide using General Procedure B-3 yielded 2-[4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-1-yl]-N,N-dimethyl-acetamide.

来源与证据

ORD记录
ord-8870564171a84c5795481a49f9373930
来源数据集
uspto-grants-2013_02
专利号
US08383620B2

关联笔记

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