乙酐 → 2-乙酰氨基吡啶-5-硼酸频哪醇酯

HRID 390937

反应方程式

HRID 390937 反应方程式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([B:8]2[O:12][C:11]([CH3:14])([CH3:13])[C:10]([CH3:16])([CH3:15])[O:9]2)=[CH:4][N:3]=1.C(N(CC)CC)C.[C:24](OC(=O)C)(=[O:26])[CH3:25]>C(Cl)Cl>[CH3:15][C:10]1([CH3:16])[C:11]([CH3:14])([CH3:13])[O:12][B:8]([C:5]2[CH:6]=[CH:7][C:2]([NH:1][C:24](=[O:26])[CH3:25])=[N:3][CH:4]=2)[O:9]1

参与物

5

反应物 3

HCID 7918乙酐HCID 8471三乙胺HCID 27565552-氨基吡啶-5-硼酸,频哪醇酯

产物 1

HCID 177502022-乙酰氨基吡啶-5-硼酸频哪醇酯

试剂、催化剂与溶剂 1

HCID 6344二氯甲烷溶剂

实验过程

To 2-amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (120 mg) in dry DCM (3 ml) and triethylamine (1.5 equiv., 114 uL) was added acetic anhydride (1.1 equiv., 57ul) and the reaction mixture was stirred at room temperature overnight. Dichloromethane/brine extraction and purification on silica gave 66 mg of N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-yl]-acetamide.

后处理

  1. extractionDichloromethane/brine extraction and purification on silica

来源与证据

ORD记录
ord-2941b3bf7cfa4cc6a87b286261c30b3a
来源数据集
uspto-grants-2013_02
专利号
US08383620B2

关联笔记

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