乙腈 → 5-Amino-4-fluoro-2-(1-methylcyclohexyl)phenol

HRID 401316

反应方程式

[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[CH3:9][C:10]1(O)[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1.CC#[N:19]>>[NH2:19][C:3]1[C:2]([F:1])=[CH:7][C:6]([C:10]2([CH3:9])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[C:5]([OH:8])[CH:4]=1

参与物

反应物 3

HCID 6342乙腈

HCID 97324-氟苯酚

HCID 115501-甲基环己醇

产物 1

HCID 574702215-Amino-4-fluoro-2-(1-methylcyclohexyl)phenol

实验过程

5-Amino-4-fluoro-2-(1-methylcyclohexyl)phenol (C-13) was synthesized following the general scheme above starting from 4-fluorophenol and 1-methylcyclohexanol. Overall yield (3%). HPLC ret. time 3.00 min, 10-99% CH3CN, 5 min run; ESI-MS 224.2 m/z (MH+).

后处理

customOverall yield (3%)

来源与证据

ORD记录: ord-1ce0f3e4c0b14bcda534347010880b6a
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08741925B2

关联笔记

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