乙酰氯 → HCID 67468600，化合物

HRID 407097

反应方程式

HRID 407097 反应方程式
[NH2:1][C:2]1[CH:3]=[C:4]([NH:18][C:19](=[O:27])[C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)[CH:5]=[CH:6][C:7]=1[C:8]1[N:12]([CH3:13])[N:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=1.CCN(C(C)C)C(C)C.[C:37](Cl)(=[O:39])[CH3:38].C(Cl)Cl.C([O-])(O)=O.[Na+]>C(Cl)Cl.O>[C:37]([NH:1][C:2]1[CH:3]=[C:4]([NH:18][C:19](=[O:27])[C:20]2[CH:21]=[CH:22][C:23]([Cl:26])=[CH:24][CH:25]=2)[CH:5]=[CH:6][C:7]=1[C:8]1[N:12]([CH3:13])[N:11]=[C:10]([C:14]([F:17])([F:15])[F:16])[CH:9]=1)(=[O:39])[CH3:38]

参与物

7

反应物 4

HCID 6367乙酰氯HCID 81531N,N-二异丙基乙胺HCID 23716255Sodium bicarbonate methylene chlorideHCID 67464229HCID 67464229，化合物

产物 1

HCID 67468600HCID 67468600，化合物

试剂、催化剂与溶剂 2

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂HCID 6344二氯甲烷溶剂

实验过程

To a solution of 17 (20 mg) in 2 ml DCM was added 3 eq DIEA and acetyl chloride (20 μl). The reaction mixture was stirred at r.t. for 5 h before worked up with DCM/NaHCO3, water. The org. phase was concentrated and subjected to prep HPLC purification to furnish compound 18.

后处理

  1. concentrationphase was concentrated
  2. customHPLC purification

来源与证据

ORD记录
ord-3de7907d9ec1449ea9857ca5a3100662
来源数据集
uspto-grants-2014_06
专利号
US08754219B2

关联笔记

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