4-(4-硝基苯基)-3-吗啉 → 4-(4-氨基苯基)吗啡啉-3-酮

HRID 41079

反应方程式

HRID 41079 反应方程式
[N:1]1([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=2)[CH2:6][CH2:5][O:4][CH2:3][C:2]1=[O:7].[H][H]>O1CCCC1.[Pd]>[N:1]1([C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)[CH2:6][CH2:5][O:4][CH2:3][C:2]1=[O:7]

参与物

5

反应物 2

HCID 114473754-(4-硝基苯基)-3-吗啉HCID 178418361HCID 178418361，化合物

产物 1

HCID 111948544-(4-氨基苯基)吗啡啉-3-酮收率 37.8%

试剂、催化剂与溶剂 2

HCID 23938钯催化剂HCID 8028四氢呋喃溶剂

实验过程

In an autoclave, 63 g (0.275 mol) of 4-(4-morpholin-3-onyl)nitrobenzene are dissolved in 200 ml of tetrahydrofuran, admixed with 3.1 g of Pd/C (5% ig) and hydrogenated at 70° C. and a hydrogen pressure of 50 bar for 8 h. The catalyst is filtered off, the solvent is then distilled off under reduced pressure and the product is purified by crystallization from ethyl acetate. 20 g of product are obtained as a colourless to bluish solid, in a yield of 37.6% of theory.

后处理

  1. filtrationThe catalyst is filtered off
  2. distillationthe solvent is then distilled off under reduced pressure
  3. customthe product is purified by crystallization from ethyl acetate

来源与证据

ORD记录
ord-7f9a54a5984e4ae4a5741f33689b95a5
来源数据集
uspto-grants-2013_09
专利号
US08530505B2

关联笔记

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