氯丙酮 → 8-(2-Methylbenzylamino)-2-methylimidazo[1,2-a]pyridine

HRID 4296

反应方程式

HRID 4296 反应方程式
[NH2:1][C:2]1[C:7]([NH:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:16])=[CH:6][CH:5]=[CH:4][N:3]=1.Cl[CH2:18][C:19](=O)[CH3:20]>C(O)C>[CH3:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[CH2:9][NH:8][C:7]1[C:2]2[N:3]([CH:18]=[C:19]([CH3:20])[N:1]=2)[CH:4]=[CH:5][CH:6]=1

参与物

4

反应物 2

HCID 6571氯丙酮HCID 138258912-Amino-3-(2-methylbenzylamino)pyridine

产物 1

HCID 201523218-(2-Methylbenzylamino)-2-methylimidazo[1,2-a]pyridine

试剂、催化剂与溶剂 1

HCID 702乙醇溶剂

实验过程

A solution of 2-amino-3-(2-methylbenzylamino)pyridine (3.25 g) and chloroacetone (1.26 ml) in ethanol (65 ml) was refluxed for 18 hours and then evaporated in vacuo. To the residue was added aqueous sodium bicarbonate solution and the mixture was extracted with methylene chloride. The extract was washed with brine, dried over magnesium sulfate, and evaporated in vacuo. The oily residue was purified by column chromatography on silica gel (40 g) with a mixture of methylene chloride and ethyl acetate (10:1) as an eluent to give 8-(2-methylbenzylamino)-2-methylimidazo[1,2-a]pyridine (1.80 g).

后处理

  1. customevaporated in vacuo
  2. additionTo the residue was added aqueous sodium bicarbonate solution
  3. extractionthe mixture was extracted with methylene chloride
  4. washThe extract was washed with brine
  5. dry with materialdried over magnesium sulfate
  6. customevaporated in vacuo
  7. customThe oily residue was purified by column chromatography on silica gel (40 g) with a mixture of methylene chloride and ethyl acetate (10:1) as an eluent

来源与证据

ORD记录
ord-022e022fa6a34c4ca3ba0dec5c804a5d
来源数据集
uspto-grants-1988_02
专利号
US04725601

关联笔记

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