氨 → Methyl 3-aminosulfonylthiophene-2-carboxylate

HRID 436831

反应方程式

HRID 436831 反应方程式
Cl[S:2]([C:5]1[CH:9]=[CH:8][S:7][C:6]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:4])=[O:3].[NH3:14]>C(Cl)(Cl)Cl>[S:2]([C:5]1[CH:9]=[CH:8][S:7][C:6]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:4])(=[O:3])[NH2:14]

参与物

4

反应物 2

HCID 222氨HCID 27367333-氯磺酰基-2-噻吩甲酸甲酯

产物 1

HCID 101012Methyl 3-aminosulfonylthiophene-2-carboxylate

试剂、催化剂与溶剂 1

HCID 6212三氯甲烷溶剂

实验过程

43.5 g (0.181 mole) of methyl 3-chlorosulfonylthiophene-2-carboxylate (VIII) is dissolved in 450 ml of absolute chloroform; ammonia is passed in at room temperature until the mixture has an alkaline reaction. After stirring the solution for a further 3 hours at room temperature (care being taken to keep the solution alkaline) it is extracted with water and the organic phase is dried and evaporated. The crystalline residue may be recrystallized from ethanol; however, for further reaction digestion with ether is sufficient.

后处理

  1. customis passed in at room temperature until the mixture
  2. customan alkaline reaction
  3. extractionis extracted with water
  4. customthe organic phase is dried
  5. customevaporated
  6. customThe crystalline residue may be recrystallized from ethanol

来源与证据

ORD记录
ord-51332c6b1b534fad9c929433efb4889c
来源数据集
uspto-grants-1977_06
专利号
US04028373

关联笔记

加载中…