Carbonic acid sodium salt (1:2) → 5-(3-溴苯基)呋喃-2-甲醛

HRID 446054

反应方程式

HRID 446054 反应方程式
C(OC(=O)CN1C(=O)/C(=C/C2OC(C3C=CC=C([Sn](CCCC)(CCCC)CCCC)C=3)=CC=2)/NC1=S)C.[CH:39]([C:41]1[O:45][C:44](B(O)O)=[CH:43][CH:42]=1)=[O:40].[Br:49][C:50]1[CH:51]=[C:52](I)[CH:53]=[CH:54][CH:55]=1.C(=O)([O-])[O-].[Na+].[Na+]>COCCOC.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[Br:49][C:50]1[CH:55]=[C:54]([C:44]2[O:45][C:41]([CH:39]=[O:40])=[CH:42][CH:43]=2)[CH:53]=[CH:52][CH:51]=1

参与物

7

反应物 4

HCID 10340Carbonic acid sodium salt (1:2)HCID 115611-溴-3-碘苯HCID 27343555-甲醛基呋喃-2-硼酸HCID 86675359(Z)-ethyl-2-(5-oxo-2-thioxo-4-((5-(3-(tributylstannyl)phenyl)furan-2-yl)methylene)imidazolidin-1-yl)acetate

产物 1

HCID 8405175-(3-溴苯基)呋喃-2-甲醛

试剂、催化剂与溶剂 2

HCID 178418397HCID 178418397，化合物催化剂HCID 8071乙二醇二甲醚溶剂

实验过程

Synthesis of (Z)-ethyl-2-(5-oxo-2-thioxo-4-((5-(3-(tributylstannyl)phenyl)furan-2-yl)methylene)imidazolidin-1-yl)acetate may be carried out in accordance with a known method, for example, a method described in non-patent document 2. First, substantially equivalent amounts of 5-formyl-2-furanboronic acid and 3-bromoiodobenzene are dissolved in 1,2-dimethoxyethane, and sodium carbonate and a catalytic amount of tetrakis(triphenylphosphine)palladium are added thereto. This solution is heated to reflux while stirring so as to carry out a reaction. After the reaction is complete, the solvent is removed by evaporation. Then, purification is carried out to give 5-(3-bromophenyl)furan-2-carbaldehyde (FIG. 1, step 1).

后处理

  1. temperatureThis solution is heated
  2. temperatureto reflux
  3. customa reaction
  4. customthe solvent is removed by evaporation
  5. customThen, purification

来源与证据

ORD记录
ord-53a0b689b8cf44aca1e2bf50b3017401
来源数据集
uspto-grants-2013_07
专利号
US08476449B2

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