氨 → 4,5-二氨基-6-氯嘧啶

HRID 447680

反应方程式

HRID 447680 反应方程式
[NH2:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[N:6][C:7]=1[Cl:8].[NH3:10]>>[Cl:8][C:7]1[N:6]=[CH:5][N:4]=[C:3]([NH2:10])[C:2]=1[NH2:1]

参与物

3

反应物 2

HCID 222氨HCID 794344,6-二氯-5-氨基嘧啶

产物 1

HCID 780104,5-二氨基-6-氯嘧啶

反应条件

温度
118 °C

实验过程

A suspension of 5-Amino-4,6-dichloropyrimidine (3 g, 0.02 mol) in ammonia (25 mL, 7N/MeOH, 0.175 mole) was heated at 118° C. overnight(under pressure). The reaction was cooled to 23° C., filtered and washed with ethanol to obtain 1.92 g (70%).

后处理

  1. temperatureThe reaction was cooled to 23° C.
  2. filtrationfiltered
  3. washwashed with ethanol
  4. customto obtain 1.92 g (70%)

来源与证据

ORD记录
ord-b09411bf28e54028a37863fd5808ffc7
来源数据集
uspto-grants-2013_07
专利号
US08481550B2

关联笔记

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