一甲胺 → 4-chloro-N-methylbutane-1-sulfonamide

HRID 455292

反应方程式

HRID 455292 反应方程式
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][S:6](Cl)(=[O:8])=[O:7].[CH2:10]([N:12](CC)CC)C.CN.C1COCC1>ClCCl>[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][S:6]([NH:12][CH3:10])(=[O:8])=[O:7]

参与物

6

反应物 4

HCID 6329一甲胺HCID 8028四氢呋喃HCID 8471三乙胺HCID 742124-氯-1-丁基磺酰氯

产物 1

HCID 103751644-chloro-N-methylbutane-1-sulfonamide

试剂、催化剂与溶剂 1

HCID 6344二氯甲烷溶剂

实验过程

To a solution of 4-chlorobutane-1-sulfonyl chloride (117 mmol) and triethyl amine (117 mmol) in dichloro methane (250 ml) at 0° C. was added a 2M solution of methyl amine in THF (117 mmol) dropwise. The mixture was allowed to warm to room temperature with stirring overnight. The organic solution was washed with H2O and extracted with CH2Cl2, dried over MgSO4 and filtered. The solution was concentrated. The product was used without further purification.

后处理

  1. washThe organic solution was washed with H2O
  2. extractionextracted with CH2Cl2
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationThe solution was concentrated
  6. customThe product was used without further purification

来源与证据

ORD记录
ord-973a1751c9bc4dd493d5322be9346561
来源数据集
uspto-grants-2013_07
专利号
US08497270B2

关联笔记

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