3-吗啉苯酚 → (2S)-2-Methoxy-3-{4-[2-(3-morpholin-4-yl-phenoxy)-ethoxy]-phenyl}-propionic acid

HRID 459343

反应方程式

HRID 459343 反应方程式
C([O:3][C:4](=[O:19])[C@@H:5]([O:17][CH3:18])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15]Br)=[CH:9][CH:8]=1)C.[N:20]1([C:26]2[CH:27]=[C:28]([OH:32])[CH:29]=[CH:30][CH:31]=2)[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1.CO[C@@H](CC1C=CC(OCCCOC2C=CC=CC=2)=CC=1)C(O)=O>>[CH3:18][O:17][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][CH2:14][CH2:15][O:32][C:28]2[CH:29]=[CH:30][CH:31]=[C:26]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[CH:27]=2)=[CH:11][CH:12]=1)[C:4]([OH:3])=[O:19]

参与物

4

反应物 3

HCID 1413433-吗啉苯酚HCID 58822865(2S)-3-[4-(2-bromo-ethoxy)-phenyl]2-methoxy-propionic acid ethyl esterHCID 58822897(2S)-2-methoxy-3-[4-(3-phenoxy propoxy)-phenyl]-propionic acid

产物 1

HCID 58822906(2S)-2-Methoxy-3-{4-[2-(3-morpholin-4-yl-phenoxy)-ethoxy]-phenyl}-propionic acid

实验过程

The title compound was prepared from (2S)-3-[4-(2-bromo-ethoxy)-phenyl]-2-methoxy-propionic acid ethyl ester (Example 283, Step 2) and 3-morpholin-4-yl-phenol via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1), to produce a yellow oil.

后处理

  1. customto produce a yellow oil

来源与证据

ORD记录
ord-3044bd01d57d4ec0a6e9ca17df8a9fb5
来源数据集
uspto-grants-2007_03
专利号
US07192982B2

关联笔记

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