三氟乙酸 → 5,7-Dichloro-4-(3-fluorophenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid ethyl ester

HRID 47366

反应方程式

HRID 47366 反应方程式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([Cl:9])[CH:8]=1)[NH2:5].[CH2:10]([C:12](=O)[C:13]([O-:15])=[O:14])[CH3:11].[F:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][CH:25]=1)C=C.F[C:27](F)(F)[C:28](O)=O>C(#N)C>[CH2:27]([O:15][C:13]([CH:12]1[CH2:10][CH:11]([C:24]2[CH:23]=[CH:20][CH:19]=[C:18]([F:17])[CH:25]=2)[C:3]2[C:4](=[CH:6][C:7]([Cl:9])=[CH:8][C:2]=2[Cl:1])[NH:5]1)=[O:14])[CH3:28]

参与物

6

反应物 4

HCID 6422三氟乙酸HCID 122813,5-二氯苯胺HCID 676913-氟苯乙烯HCID 35932772-Ketobutyrate

产物 1

HCID 101770425,7-Dichloro-4-(3-fluorophenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid ethyl ester收率 44%

试剂、催化剂与溶剂 1

HCID 6342乙腈溶剂

实验过程

Compound 8 was prepared in a yield of 44% by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 3-fluorostyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.

来源与证据

ORD记录
ord-6a6a5889fc1b45e8a0c8a73ca50c5422
来源数据集
uspto-grants-2004_03
专利号
US06699877B2

关联笔记

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