N,N-二甲基甲酰胺 → HCID 178526937，化合物

HRID 47460

反应方程式

HRID 47460 反应方程式
[O-:1]CC.[K+].[CH3:5][C:6]1[N:10]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][C:16]=2[C:17]([O:19]CC)=O)[N:9]=[N:8][N:7]=1.CN(C)C=O>C(O)(=O)C>[OH2:1].[N:9]1[N:10]2[C:11]3[C:16]([C:17]([OH:19])=[CH:5][C:6]2=[N:7][N:8]=1)=[CH:15][CH:14]=[N:13][CH:12]=3

参与物

5

反应物 3

HCID 6228N,N-二甲基甲酰胺HCID 22172739ethyl 3-(5-methyl-1H-tetrazol-1-yl)pyridine-4-carboxylateHCID 23670592乙醇钾

产物 1

HCID 178526937HCID 178526937，化合物收率 90.9%

试剂、催化剂与溶剂 1

HCID 176醋酸溶剂

实验过程

Potassium ethoxide (20.2 g) was added to a mixture of ethyl 3-(5-methyl-1H-tetrazol-1-yl)pyridine-4-carboxylate (28 g) and dimethylformamide (280 mL). The reaction mixture was allowed to stir at ambient temperature overnight then poured into cold dilute acetic acid. The resulting precipitate was collected, washed with water and dried to provide 22.4 g of tetrazolo[1,5-a][1,7]naphthyridin-5-ol hydrate as a solid, m.p. 247-248° C. (decomposition). Analysis: Calculated for C8H5N5O: %C, 46.83; %H, 3.44; %N, 34.13. Found: %C, 46.48; %H, 3.42; %N, 34.03.

后处理

  1. customThe resulting precipitate was collected
  2. washwashed with water
  3. customdried

来源与证据

ORD记录
ord-bd0cdde275de498d9a53580003c5b510
来源数据集
uspto-grants-2004_03
专利号
US06699878B2

关联笔记

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