DL-甘油醛 → Benzyl 4,5-dihydroxy-2-pentenoate

HRID 489063

反应方程式

HRID 489063 反应方程式
[CH2:1]([OH:6])[CH:2]([OH:5])[CH:3]=O.[Br-].[CH2:8]([O:15][C:16]([CH2:18][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:17])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>O1C(CC)C1>[OH:5][CH:2]([CH2:1][OH:6])[CH:3]=[CH:18][C:16]([O:15][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:17]

参与物

4

反应物 2

HCID 751DL-甘油醛HCID 11214019(苄氧羰基甲基)三苯基溴化膦

产物 1

HCID 54529065Benzyl 4,5-dihydroxy-2-pentenoate

试剂、催化剂与溶剂 1

HCID 78341,2-环氧丁烷溶剂

实验过程

A mixture of DL-glycerinaldehyde (4.5 g, 50 mmole) and (benzyloxycarbonylmethyl)-triphenyl-phosphoniumbromide (24.57 g, 50 mmole) in 100 ml 1,2-epoxybutane was refluxed overnight. The mixture was evaporated under vacuum and the product was isolated by silica gel column chromatography.

后处理

  1. temperaturewas refluxed overnight
  2. customThe mixture was evaporated under vacuum
  3. customthe product was isolated by silica gel column chromatography

来源与证据

ORD记录
ord-274a806608864003b6ffad9050318002
来源数据集
uspto-grants-2005_12
专利号
US06974802B2

关联笔记

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