丙酰胺 → N-(4-{4-[5-(2-ethoxy-ethyl)-2,4,6-trioxo-hexahydro-pyrimidin-5-yloxy]-phenoxy}-benzyl)-propionamide

HRID 49151

反应方程式

HRID 49151 反应方程式
[OH:1][C:2]1[CH:20]=[CH:19][C:5]([O:6][C:7]2[CH:18]=[CH:17][C:10]([CH2:11][NH:12][C:13](=[O:16])[CH2:14][CH3:15])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.Br[C:22]1([CH2:31][CH2:32][O:33][CH2:34][CH3:35])[C:27](=[O:28])[NH:26][C:25](=[O:29])[NH:24][C:23]1=[O:30].CCCCC=CCCCC.C1(F)(C2(F)OC(C(F)(F)F)(C(F)(F)F)OC2(F)F)OC(C(F)(F)F)(C(F)(F)F)OC1(F)F.C(N)(=O)CC>C(#N)C>[CH2:34]([O:33][CH2:32][CH2:31][C:22]1([O:1][C:2]2[CH:3]=[CH:4][C:5]([O:6][C:7]3[CH:18]=[CH:17][C:10]([CH2:11][NH:12][C:13](=[O:16])[CH2:14][CH3:15])=[CH:9][CH:8]=3)=[CH:19][CH:20]=2)[C:23](=[O:30])[NH:24][C:25](=[O:29])[NH:26][C:27]1=[O:28])[CH3:35]

参与物

7

反应物 5

HCID 6578丙酰胺HCID 239165-DeceneHCID 1974084,4',5,5,5',5'-Hexafluoro-2,2,2',2'-tetrakis(trifluoromethyl)-4,4'-bi-1,3-dioxolaneHCID 20636237N-[4-(4-Hydroxy-phenoxy)-benzyl]-propionamideHCID 219311235-Bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione

产物 1

HCID 20636226N-(4-{4-[5-(2-ethoxy-ethyl)-2,4,6-trioxo-hexahydro-pyrimidin-5-yloxy]-phenoxy}-benzyl)-propionamide

试剂、催化剂与溶剂 1

HCID 6342乙腈溶剂

实验过程

Following the procedure outlined for the preparation of Example 1, N-[4-(4-hydroxy-phenoxy)-benzyl]-propionamide (0.13 g, 0.47 mmol) was reacted with 5-bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione (0.13 g, 0.48 mmol), 1,5,7-trazabicyclo[4.4.0]dec-5-ene bound to polystyrene crosslinked with 2% DVB (PTBD, Fluka, 0.31 g) and 1.55 mL of acetonitrile, benzyl)-propionamide (0.060 g) as a colorless solid.

来源与证据

ORD记录
ord-4a89fc67434542439b5e46a12ded1604
来源数据集
uspto-grants-2004_03
专利号
US06706723B2

关联笔记

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