氟磺酸甲酯 → (2S)-1,1-Dimethyl-2-(4-methoxybenzylthiomethyl)pyrrolidinium fluorosulfonate

HRID 5109

反应方程式

HRID 5109 反应方程式
[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]([CH2:7][S:8][CH2:9][C@@H:10]2[CH2:14][CH2:13][CH2:12][N:11]2[CH3:15])=[CH:5][CH:4]=1.[F:18][S:19]([O:22][CH3:23])(=[O:21])=[O:20]>C(Cl)Cl>[F:18][S:19]([O-:22])(=[O:21])=[O:20].[CH3:15][N+:11]1([CH3:23])[CH2:12][CH2:13][CH2:14][C@H:10]1[CH2:9][S:8][CH2:7][C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:17][CH:16]=1

参与物

4

反应物 2

HCID 9870氟磺酸甲酯HCID 57048351(2S)-2-(4-Methoxybenzylthiomethyl)-1-methylpyrrolidine

产物 1

HCID 14880299(2S)-1,1-Dimethyl-2-(4-methoxybenzylthiomethyl)pyrrolidinium fluorosulfonate

试剂、催化剂与溶剂 1

HCID 6344二氯甲烷溶剂

实验过程

The procedure described in Preparation 5-(5) was repeated, but using 740 mg of (2S)-2-(4-methoxybenzylthiomethyl)-1-methylpyrrolidine and 243 μl of methyl fluorosulfonate in the presence of 22 ml of methylene chloride, to afford 1.0 g of the title compound as crystals, melting at 150°-153° C.

后处理

  1. customThe procedure described in Preparation 5-(5)

来源与证据

ORD记录
ord-5a0095e69f164f00815bcbd1c99cbbde
来源数据集
uspto-grants-1993_09
专利号
US05242914

关联笔记

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