氢氧化钾 → [(1-Chloro-4-methoxy-isoquinoline-3-carbonyl)-amino]-acetic acid

HRID 523780

反应方程式

HRID 523780 反应方程式
C[O:2][C:3](=[O:21])[CH2:4][NH:5][C:6]([C:8]1[N:9]=[C:10]([Cl:20])[C:11]2[C:16]([C:17]=1[O:18][CH3:19])=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:7].[OH-].[K+]>CCO>[Cl:20][C:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:17]([O:18][CH3:19])=[C:8]([C:6]([NH:5][CH2:4][C:3]([OH:21])=[O:2])=[O:7])[N:9]=1

参与物

4

反应物 2

HCID 14797氢氧化钾HCID 86014583[(1-Chloro-4-methoxy-isoquinoline-3-carbonyl)-amino]-acetic acid methyl ester

产物 1

HCID 11737975[(1-Chloro-4-methoxy-isoquinoline-3-carbonyl)-amino]-acetic acid

试剂、催化剂与溶剂 1

HCID 702乙醇溶剂

实验过程

A mixture of [(1-chloro-4-methoxy-isoquinoline-3-carbonyl)-amino]-acetic acid methyl ester (21 mg, 0.07 mmol), KOH (23 mg, 0.35 mmol) and EtOH (1 ml) was stirred at ambient temperature for 3 h. Then the solvent was evaporated in vacuo. The residue was dissolved in water (2 ml) and the pH of the solution was adjusted to 2-3 by the addition of aqueous 1N HCl. The mixture was extracted with EtOAc (4×10 ml). The combined org. phases were dried over MgSO4 and evaporated in vacuo to give the title compound as a slightly yellowish solid (18 mg); MS-(+)-ion: M+1=295.0.

后处理

  1. customThen the solvent was evaporated in vacuo
  2. dissolutionThe residue was dissolved in water (2 ml)
  3. additionthe pH of the solution was adjusted to 2-3 by the addition of aqueous 1N HCl
  4. extractionThe mixture was extracted with EtOAc (4×10 ml)
  5. dry with materialphases were dried over MgSO4
  6. customevaporated in vacuo

来源与证据

ORD记录
ord-a59050eced80476f9bb3bb5ab6e1bff2
来源数据集
uspto-grants-2016_05
专利号
US09339527B2

关联笔记

加载中…