苯酐 → 5-[2-[2-(Carboxy)benzoylamino]ethylthio]imidazo[1,2-a]pyridine

HRID 5444

反应方程式

HRID 5444 反应方程式
[NH2:1][CH2:2][CH2:3][S:4][C:5]1[N:10]2[CH:11]=[CH:12][N:13]=[C:9]2[CH:8]=[CH:7][CH:6]=1.[C:14]1(=[O:24])[O:19][C:17](=[O:18])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12>C(Cl)(Cl)Cl>[C:17]([C:16]1[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=1[C:14]([NH:1][CH2:2][CH2:3][S:4][C:5]1[N:10]2[CH:11]=[CH:12][N:13]=[C:9]2[CH:8]=[CH:7][CH:6]=1)=[O:24])([OH:19])=[O:18]

参与物

4

反应物 2

HCID 6811苯酐HCID 152293695-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine

产物 1

HCID 233628395-[2-[2-(Carboxy)benzoylamino]ethylthio]imidazo[1,2-a]pyridine收率 84.8%

试剂、催化剂与溶剂 1

HCID 6212三氯甲烷溶剂

实验过程

To a solution of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine (1.12 g, 5.8 mmoles) in chloroform (58 ml) was added phthalic anhydride (1.12 g, 7.56 mmoles) and the mixture was stirred at room temperature for 14 hours and then heated at reflux for 5 hours. The reaction mixture was cooled by standing. The crystals precipitated were filtered off, washed with chloroform and dried to obtain 1.68 g of the desired product (84.8%, colorless crystals).

后处理

  1. temperatureheated
  2. temperatureat reflux for 5 hours
  3. temperatureThe reaction mixture was cooled
  4. customThe crystals precipitated
  5. filtrationwere filtered off
  6. washwashed with chloroform
  7. customdried

来源与证据

ORD记录
ord-201221c47b48468e8dcff804deda74d1
来源数据集
uspto-grants-1993_09
专利号
US05244908

关联笔记

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