2-氨基苯乙腈 → 1H-吲唑-3-甲腈

HRID 549067

反应方程式

HRID 549067 反应方程式
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][C:5]#[N:6].[N:11]([O-])=O.[Na+]>Cl>[C:5]([C:4]1[C:3]2[C:2](=[CH:10][CH:9]=[CH:8][CH:7]=2)[NH:1][N:11]=1)#[N:6]

参与物

4

反应物 2

HCID 763072-氨基苯乙腈HCID 23668193亚硝酸钠

产物 1

HCID 4375561H-吲唑-3-甲腈

试剂、催化剂与溶剂 1

HCID 313海萝胶溶剂

实验过程

A solution of o-aminobenzyl cyanide (0.5 g) in aqueous hydrochloric acid 1N (9.6 mL), was treated with a solution of aqueous sodium nitrite 1N (3.85 mL). After stirring at room temperature for 15 minutes, the reaction mixture was filtered. The solid was recrystallised from ethanol to give the title compound (0.4 g) as a yellow solid, m.p. 138-140° C. 1H NMR [(CD3)2SO]: δ 7.89 (d, 1H, J=7.7 Hz); 7.76 (d, 1H, J=7.9 Hz); 7.48 (t, 1H); 7.41 (t, 1H).

后处理

  1. filtrationthe reaction mixture was filtered
  2. customThe solid was recrystallised from ethanol

来源与证据

ORD记录
ord-99b2645688ee40448ec16adfb554ec7a
来源数据集
uspto-grants-2011_05
专利号
US07943616B2

关联笔记

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