海萝胶 → 5-Hydroxy-5-(1-methyl-2-pyrrolyl)-2,4,6-(1H,3H,5H)pyrimidinetrione

HRID 580550

反应方程式

HRID 580550 反应方程式
O.[NH:2]1[C:10](=[O:11])[C:8](=[O:9])[C:6](=[O:7])[NH:5][C:3]1=[O:4].[CH3:12][N:13]1[CH:17]=[CH:16][CH:15]=[CH:14]1.Cl>C(O)C>[OH:9][C:8]1([C:14]2[N:13]([CH3:12])[CH:17]=[CH:16][CH:15]=2)[C:6](=[O:7])[NH:5][C:3](=[O:4])[NH:2][C:10]1=[O:11]

参与物

5

反应物 3

HCID 313海萝胶HCID 7304N-甲基吡咯HCID 16723阿脲一水合物

产物 1

HCID 212712485-Hydroxy-5-(1-methyl-2-pyrrolyl)-2,4,6-(1H,3H,5H)pyrimidinetrione收率 65%

试剂、催化剂与溶剂 1

HCID 702乙醇溶剂

实验过程

Alloxan hydrate (3.2 g., 0.02 mole) was dissolved in 50 ml. of ethanol by warming. 1-Methylpyrrole (1.6 g., 0.02 mole) was added and the mixture warmed for 5 minutes on a steam bath, while perfusing with hydrogen chloride. After standing at room temperature for 0.5 hour, the reaction mixture was evaporated to dryness and the residue triturated with water to yield title product as a solid [2.9 g.; m/e 223; Rf 0.5 (1:1 ethyl acetate:hexane/5% acetic acid)].

后处理

  1. temperaturethe mixture warmed for 5 minutes on a steam bath
  2. customthe reaction mixture was evaporated to dryness
  3. customthe residue triturated with water

来源与证据

ORD记录
ord-3b9bf827d1a24618ad85cf536806ac10
来源数据集
uspto-grants-1988_06
专利号
US04753956

关联笔记

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