氨 → 1H-Indole-5-carboxylic acid(4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride

HRID 599198

反应方程式

HRID 599198 反应方程式
[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@@H:5]3[NH2:12])[CH2:3]1)[CH2:9]2.[NH:13]1[C:21]2[C:16](=[CH:17][C:18]([C:22](O)=[O:23])=[CH:19][CH:20]=2)[CH:15]=[CH:14]1.N>>[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@@H:5]3[NH:12][C:22]([C:18]3[CH:17]=[C:16]4[C:21](=[CH:20][CH:19]=3)[NH:13][CH:14]=[CH:15]4)=[O:23])[CH2:3]1)[CH2:9]2

参与物

4

反应物 3

HCID 222氨HCID 74280吲哚-5-羧酸HCID 671521221-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride

产物 1

HCID 671521061H-Indole-5-carboxylic acid(4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride

实验过程

Prepared from (4s)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and indole-5-carboxylic acid (Aldrich) according to methods A and C; yield 27 mg, 0.08 mmol (37%): 1H NMR (300 MHz, methanol-d4) δ 1.97 (d, J=13 Hz, 2H), 2.21 (s, 1H), 2.37 (d, J=14 Hz, 2H), 2.49 (s, 2H), 3.58 (s, 2H), 3.69 (s, 4H), 4.42 (s, 1H), 6.57 (dd, J=3, 1 Hz, 1H), 7.34 (d, J=3 Hz, 1H), 7.45 (d, J=8 Hz, 1H), 7.64 (dd, J=9, 2 Hz, 1H), 8.10-8.17 (m, 2H); MS (DCI/NH3) m/z 296 (M+H)+; Anal. C18H21N3O.HCl.0.5H2O: C, H, N.

来源与证据

ORD记录
ord-c949a0220dea4533a52b1ab5201531fe
来源数据集
uspto-grants-2011_03
专利号
US07897766B2

关联笔记

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