三溴化硼 → 4-溴邻苯二酚

HRID 603092

反应方程式

HRID 603092 反应方程式
[Br:1][C:2]1[CH:3]=[C:4]([O:10]C)[C:5]([O:8]C)=[CH:6][CH:7]=1.B(Br)(Br)Br>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]([OH:10])[C:5](=[CH:6][CH:7]=1)[OH:8]

参与物

4

反应物 2

HCID 25134三溴化硼HCID 761144-溴黎芦醚

产物 1

HCID 284874-溴邻苯二酚收率 96.1%

试剂、催化剂与溶剂 1

HCID 6344二氯甲烷溶剂

实验过程

6.51 g (0.0300 mol) of 4-bromoveratrole is dissolved in 50 ml of dichloromethane. To this suspension is added 37.6 g (0.150 mol) of boron tribromide at 0° C. The mixture was stirred for 3 hours at room temperature. Solvents were removed under reduced pressure. The resulting brown oil was dissolved in ethyl acetate and filtered through a pad of silica gel. The filtrate was concentrated to afford 5.45 g of 4-bromo catechol as a fight, brown oil.

后处理

  1. customSolvents were removed under reduced pressure
  2. dissolutionThe resulting brown oil was dissolved in ethyl acetate
  3. filtrationfiltered through a pad of silica gel
  4. concentrationThe filtrate was concentrated

来源与证据

ORD记录
ord-78a19679612140a9b7842b32d540d6c0
来源数据集
uspto-grants-2011_03
专利号
US07906648B2

关联笔记

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