愈创木酚 → 4-[5-(2-Methoxyphenoxy)pentoxy]benzonitrile

HRID 6070

反应方程式

HRID 6070 反应方程式
[C:1]1([O:8][CH3:9])[C:2](=[CH:4][CH:5]=[CH:6][CH:7]=1)[OH:3].[H-].[Na+].[H][H].I[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][O:20][C:21]1[CH:28]=[CH:27][C:24]([C:25]#[N:26])=[CH:23][CH:22]=1>CN(C=O)C.O>[CH3:9][O:8][C:1]1[CH:7]=[CH:6][CH:5]=[CH:4][C:2]=1[O:3][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][O:20][C:21]1[CH:22]=[CH:23][C:24]([C:25]#[N:26])=[CH:27][CH:28]=1

参与物

7

反应物 4

HCID 460愈创木酚HCID 24758氢化钠HCID 16202445Benzonitrile, 4-[(5-iodopentyl)oxy]-HCID 178418361HCID 178418361，化合物

产物 1

HCID 197948854-[5-(2-Methoxyphenoxy)pentoxy]benzonitrile

试剂、催化剂与溶剂 2

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂HCID 6228N,N-二甲基甲酰胺溶剂2 次

实验过程

To a solution of 5.1 g (41 mmol) of guaiacol in 41 mL of DMF, cooled in an icebath, is added in portions, 20 g (41 mmole) of sodium hydride (50% dispersion in oil). The reaction is allowed to warm up to room temperature and stirred until no further hydrogen evolution is observed. The solution is then again cooled in an ice-bath and a solution of 13 g (41 mmol) 4-(5-iodopentoxy) benzonitrile in 82 mL DMF added. The reaction is allowed to warm up to room temperature and stirred for 18 h before pouring the mixture into water. The resulting solid is filtered off and dried to give 4-[5-(2-methoxyphenoxy)pentoxy] benzonitrile, m.p. 61°-63° C.

后处理

  1. temperatureThe solution is then again cooled in an ice-bath
  2. temperatureto warm up to room temperature
  3. filtrationThe resulting solid is filtered off
  4. customdried

来源与证据

ORD记录
ord-fdd2eb38b67e4d6b8e06115e859cab46
来源数据集
uspto-grants-1993_09
专利号
US05246965

关联笔记

加载中…