海萝胶 → 氟哌酸盐酸盐

HRID 614907

反应方程式

HRID 614907 反应方程式
O.O.O.O.O.[CH2:6]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([F:24])=[C:15]([N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[CH:16]=2)[C:11](=[O:25])[C:10]([C:26]([OH:28])=[O:27])=[CH:9]1)[CH3:7].C(N1C2C(=CC(F)=C(N3CCNCC3)C=2)C(=O)C(C(O)=O)=C1)C.[ClH:52]>C(O)C>[ClH:52].[CH2:6]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([F:24])=[C:15]([N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[CH:16]=2)[C:11](=[O:25])[C:10]([C:26]([OH:28])=[O:27])=[CH:9]1)[CH3:7]

参与物

5

反应物 3

HCID 313海萝胶HCID 4539诺氟沙星HCID 706035241-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid pentahydrate

产物 1

HCID 12733888氟哌酸盐酸盐

试剂、催化剂与溶剂 1

HCID 702乙醇溶剂

实验过程

The compound (I) or (II) was dissolved in ethanol and acidified with concentrated hydrochloric acid. The resulting precipitate was collected, washed with ethanol, and dried to give 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride (III) as colorless needles, m.p. above 300° C.

后处理

  1. customThe resulting precipitate was collected
  2. washwashed with ethanol
  3. customdried

来源与证据

ORD记录
ord-9db6c02d96a74a82888d23a4fe2324b2
来源数据集
uspto-grants-1979_03
专利号
US04146719

关联笔记

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