海萝胶 → 9-Amino-1,2,3,4-tetrahydroacridine hydrate

HRID 6221

反应方程式

HRID 6221 反应方程式
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[C:10]1(=[O:16])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1.Cl>>[OH2:16].[NH2:5][C:4]1[C:3]2[C:2]([N:1]=[C:10]3[C:11]=1[CH2:12][CH2:13][CH2:14][CH2:15]3)=[CH:9][CH:8]=[CH:7][CH:6]=2

参与物

4

反应物 3

HCID 313海萝胶2 次HCID 7967环己酮HCID 729132-氨基苯甲腈

产物 1

HCID 197952369-Amino-1,2,3,4-tetrahydroacridine hydrate收率 67%

实验过程

A mixture of 2-aminobenzonitrile (120 g), cyclohexanone (115.8 ml), conc hydrochloric acid (9.2 ml), and cuprous chloride (1.21 g) was heated under reflux for 3 days, with stirring. At the end of each 24 hr period, additional cuprous chloride (1.21 g) was added. At the end of the 3rd day, additional conc hydrochloric acid (47.3 ml) was added, and the mixture was cooled to ambient temperature. The precipitate was collected and washed with 10% hydrochloric acid to provide 160 g (67.0%) of 9-amino-1,2,3,4-tetrahydroacridine hydrate, mp 180°-185°.

后处理

  1. temperaturewas heated
  2. temperatureunder reflux for 3 days
  3. customThe precipitate was collected
  4. washwashed with 10% hydrochloric acid

来源与证据

ORD记录
ord-ef26d013c4cc405e8068592ad63dfa26
来源数据集
uspto-grants-1993_09
专利号
US05247091

关联笔记

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