(S)-2-氨基-2-苯乙酰胺盐酸盐 → 5-Cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid ((S)-carbamoyl-phenyl-methyl)-amide

HRID 632361

反应方程式

HRID 632361 反应方程式
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:16]([OH:18])=O)=[N:8][C:9]=2[O:10][CH2:11][C:12]([F:15])([F:14])[F:13])[CH2:3][CH2:2]1.Cl.[NH2:20][C@@H:21]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:22]([NH2:24])=[O:23]>>[C:22]([C@@H:21]([NH:20][C:16]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][C:12]([F:13])([F:14])[F:15])[N:8]=1)=[O:18])[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)(=[O:23])[NH2:24]

参与物

3

反应物 2

HCID 22850726(S)-2-氨基-2-苯乙酰胺盐酸盐HCID 710876495-Cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid

产物 1

HCID 711130705-Cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid ((S)-carbamoyl-phenyl-methyl)-amide

实验过程

The title compound was synthesized in analogy to Example 280c, using 5-cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 301a) and (S)-2-amino-2-phenyl-acetamide hydrochloride (CAN 60079-51-8) as starting materials, MS (EI): m/e=394.1 [M+H]+.

来源与证据

ORD记录
ord-f79bfcd687f94d3ab0e3ca09c9f155f6
来源数据集
uspto-grants-2016_04
专利号
US09321727B2

关联笔记

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