海萝胶 → 3-氯-4-氟苯甲酸

HRID 635543

反应方程式

HRID 635543 反应方程式
C[C:2]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[C:6]([Cl:11])[CH:5]=1)=[O:3].Br[O-].[Na+].S([O-])(O)=[O:16].[Na+].Cl>>[Cl:11][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[F:10])[C:2]([OH:3])=[O:16]

参与物

5

反应物 4

HCID 313海萝胶HCID 5204223-氯-4-氟苯乙酮HCID 23665763亚硫酸氢钠HCID 23673712次溴酸钠

产物 1

HCID 5209893-氯-4-氟苯甲酸收率 74%

实验过程

The 3-chloro-4-fluoroacetophenone is then reacted with an aqueous solution of sodium hypobromite, the aqeuous phase is treated with sodium hydrogensulfite and acidified with hydrochloric acid, and the precipitated product is recrystallized from benzene. 3-Chloro-4-fluorobenzoic acid obtained in a yield of 74%.

后处理

  1. customthe precipitated product is recrystallized from benzene

来源与证据

ORD记录
ord-d546c0be93c5496da77831fb43df7de5
来源数据集
uspto-grants-2001_02
专利号
US06187952B1

关联笔记

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