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咪唑 → 1-(Tert-butyldiphenylsilyloxymethyl)-2,6-dichloro-3-nitrobenzene
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 咪唑 | HCID 795 | — |
| 反应物 | 叔丁基二苯基氯硅烷 | HCID 94078 | — |
| 反应物 | (2,6-二氯-3-硝基)苯甲醇 | HCID 2794914 | — |
| 溶剂 | 聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] | HCID 962 | — |
| 溶剂 | N,N-二甲基甲酰胺 | HCID 6228 | — |
| 产物 | 1-(Tert-butyldiphenylsilyloxymethyl)-2,6-dichloro-3-nitrobenzene | HCID 11798185 | — |
反应步骤
To a solution of 2,6-dichloro-3-nitrobenzyl alcohol (5.0 g) in N,N-dimethylformamide (25 ml) were added imidazole (1.69 g) and tert-butyldiphenylsilyl chloride (6.0 ml) at ambient temperature with stirring. After 8 hours, the mixture was diluted with water (25 ml) and was extracted with ethyl acetate twice. The organic layer was washed with water and brine, dried over magnesium sulfate. The solvent was removed in vacuo to give 1-(tert-butyldiphenylsilyloxy-methyl)-2,6-dichloro-3-nitrobenzene (11.5 g) as an oil.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US06194396B1 |
| 来源数据集 | uspto-grants-2001_02 |
| ORD ID | ord-d0f516dca2d644df921aba87cd07eca9 |
| 来源说明 | uspto-grants-2001_02 |