5-甲基吲哚 → 5-甲基二氢吲哚

HRID 645326

反应方程式

HRID 645326 反应方程式
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.COC1C=C2C(=CC=1)NCC2.C([BH3-])#N.[Na+]>C(O)(=O)C>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH2:6][CH2:5]2

参与物

5

反应物 3

HCID 119785-甲基吲哚2 次HCID 5003444氰基硼氢化钠HCID 107019745-甲氧基吲哚啉

产物 1

HCID 140236795-甲基二氢吲哚收率 99%

试剂、催化剂与溶剂 1

HCID 176醋酸溶剂

实验过程

5-Methylindoline was prepared from 5-methylindole using the procedure described for the preparation of 5-methoxyindoline. 5-Methylindole (11 g, 0.0835 mol) in glacial acetic acid (150 mL) in a 1 L 3-necked flask was reduced at 10-15° C. with sodium cyanoborohydride (15.8 g, 0.251 mol). Extraction with ethyl acetate provided 5-methylindoline (11 g, 0.0832 mol, 99% yield) as a thick oil which was used without further purification. The structure was corroborated by NMR spectroscopy.

后处理

  1. extractionExtraction with ethyl acetate

来源与证据

ORD记录
ord-d01d4c3cbc214279923b9c09f839446b
来源数据集
uspto-grants-2010_04
专利号
US07704667B2

关联笔记

加载中…