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N-(2-Cyano-ethyl)-N-methyl-2-piperazin-1-yl-acetamide dihydrochloride → 2-{4-[(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N-(2-cyano-ethyl)-N-methyl-acetamide
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | N-(2-Cyano-ethyl)-N-methyl-2-piperazin-1-yl-acetamide dihydrochloride | HCID 67246240 | — |
| 反应物 | cis-4,5-Bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl chloride | HCID 86613636 | — |
| 产物 | 2-{4-[(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N-(2-cyano-ethyl)-N-methyl-acetamide | HCID 58923204 | — |
反应步骤
2-{4-[(4S,5R)-4,5-Bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 34) was reacted with N-(2-cyano-ethyl)-N-methyl-2-piperazin-1-yl-acetamide dihydrochloride to give 2-{4-[(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N-(2-cyano-ethyl)-N-methyl-acetamide in an analogous manner as described in example 1. LR-MS: 653.2 [(M+H)+].
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US07705007B2 |
| 来源数据集 | uspto-grants-2010_04 |
| ORD ID | ord-de55aacf042743f68a2d1a26184ef533 |
| 来源说明 | uspto-grants-2010_04 |