硫酸卡那霉素 → 卡那霉素A

HRID 654731

反应方程式

HRID 654731 反应方程式
[CH2:1]1[C@H:6]([NH2:7])[C@@H:5]([O:8][C@H:9]2[O:14][C@H:13]([CH2:15][NH2:16])[C@@H:12]([OH:17])[C@H:11]([OH:18])[C@H:10]2[OH:19])[C@H:4]([OH:20])[C@@H:3]([O:21][C@H:22]2[O:27][C@H:26]([CH2:28][OH:29])[C@@H:25]([OH:30])[C@H:24]([NH2:31])[C@H:23]2[OH:32])[C@@H:2]1[NH2:33].OS(O)(=O)=O>ClCCl>[CH2:1]1[C@H:6]([NH2:7])[C@@H:5]([O:8][C@H:9]2[O:14][C@H:13]([CH2:15][NH2:16])[C@@H:12]([OH:17])[C@H:11]([OH:18])[C@H:10]2[OH:19])[C@H:4]([OH:20])[C@@H:3]([O:21][C@H:22]2[O:27][C@H:26]([CH2:28][OH:29])[C@@H:25]([OH:30])[C@H:24]([NH2:31])[C@H:23]2[OH:32])[C@@H:2]1[NH2:33]

参与物

3

反应物 1

HCID 441374硫酸卡那霉素

产物 1

HCID 6032卡那霉素A

试剂、催化剂与溶剂 1

HCID 6344二氯甲烷溶剂

实验过程

To a solution of 125 ml of dichloromethane was added 1 gram of kanamycin sulfate in 10 ml of aqueous solution. To the resulting solution was added 20 ml of soy lecithin (Alcolec S). The solution was mixed by shaking. Four ml of the solution was applied to each side of a 1"×1" foam wound dressing, which was then allowed to dry. These materials were placed in foil heat sealed bags and subjected to sterilization by use of cobalt irradiation (3.2 megarads). The materials were assayed for antibiotic activity as described in Example 12. The eluent contained fully active entrapped antibiotic after irradiation by using standard antimicrobial assay techniques.

后处理

  1. additionThe solution was mixed
  2. customto dry
  3. temperatureheat
  4. customsealed bags
  5. customsubjected to sterilization by use of cobalt irradiation (3.2 megarads)
  6. customafter irradiation

来源与证据

ORD记录
ord-9d170c3bf22e4db09cd77edb21210d79
来源数据集
uspto-grants-1992_07
专利号
US05133965

关联笔记

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