3,4,5-三甲氧基苯甲醛 → Tetrahydro-3,5-bis[(3,4,5-trimethoxyphenyl)methylene]-4H-pyran-4-one

HRID 65672

反应方程式

HRID 65672 反应方程式
[O:1]1[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]1.[CH3:8][O:9][C:10]1[CH:11]=[C:12]([CH:15]=[C:16]([O:20][CH3:21])[C:17]=1[O:18][CH3:19])[CH:13]=O>CCO.Cl>[CH3:8][O:9][C:10]1[CH:11]=[C:12]([CH:13]=[C:3]2[C:4](=[O:7])[C:5](=[CH:13][C:12]3[CH:15]=[C:16]([O:20][CH3:21])[C:17]([O:18][CH3:19])=[C:10]([O:9][CH3:8])[CH:11]=3)[CH2:6][O:1][CH2:2]2)[CH:15]=[C:16]([O:20][CH3:21])[C:17]=1[O:18][CH3:19]

参与物

5

反应物 2

HCID 68583,4,5-三甲氧基苯甲醛HCID 121599四氢吡喃酮

产物 1

HCID 2740872Tetrahydro-3,5-bis[(3,4,5-trimethoxyphenyl)methylene]-4H-pyran-4-one

试剂、催化剂与溶剂 2

HCID 313海萝胶溶剂HCID 702乙醇溶剂

实验过程

A solution of 6.0 g (0.06 mole) of tetrahydro-4H-pyran-4-one and 25 g (0.127 mole) of 3,4,5-trimethoxybenzaldehyde in 75 ml of EtOH and 10 ml of concentrated HCl is stirred and heated at reflux for 3 hours. The product gradually precipitates from the cooled solution. The yield of yellow crystals is 12.0 g (44%), m.p. 187°-189°.

后处理

  1. temperatureheated
  2. temperatureat reflux for 3 hours
  3. customThe product gradually precipitates from the cooled solution

来源与证据

ORD记录
ord-48d5a20802204161ac721fb022201aab
来源数据集
uspto-grants-1978_12
专利号
US04128648

关联笔记

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