1,1-二甲基肼 → alpha-Dimethylhydrazinocarbonylamino-2-thiopheneacetic acid

HRID 65796

反应方程式

HRID 65796 反应方程式
[N:1]([CH:4]([C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)[C:5]([O:7]CC)=[O:6])=[C:2]=[O:3].[CH3:15][N:16]([CH3:18])[NH2:17].C(Cl)Cl>C(O)(=O)C>[CH3:15][N:16]([CH3:18])[NH:17][C:2]([NH:1][CH:4]([C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)[C:5]([OH:7])=[O:6])=[O:3]

参与物

5

反应物 3

HCID 59761,1-二甲基肼HCID 6344二氯甲烷HCID 54068691alpha-Isocyanato-2-thiopheneacetic acid, ethyl ester

产物 1

HCID 54530029alpha-Dimethylhydrazinocarbonylamino-2-thiopheneacetic acid

试剂、催化剂与溶剂 1

HCID 176醋酸溶剂

实验过程

A solution of 4.2 g. (0.02 mole) of DL-α-isocyanato-2-thiopheneacetic acid, ethyl ester and 1.2 g. (0.02 mole) of N,N-dimethylhydrazine in 80 ml. of methylene chloride is stirred overnight. The solution is concentrated and to the syrupy residue are added 10 ml. of 2N sodium hydroxide solution. After stirring for 30 minutes, a clear yellow solution results. By the addition of acetic acid, 3.9 g. of α-dimethylhydrazinocarbonylamino-2-thiopheneacetic acid are obtained, m.p. 208°-210°.

后处理

  1. concentrationThe solution is concentrated and to the syrupy residue
  2. additionare added 10 ml
  3. customa clear yellow solution results

来源与证据

ORD记录
ord-208d1fa98d07437e8ee5455d106b3405
来源数据集
uspto-grants-1978_12
专利号
US04128724

关联笔记

加载中…