N-(4-甲氧基苄基)-N-甲胺 → 4-(N-(4-methoxybenzyl)-N-methylsulfamoyl)benzoic acid

HRID 658627

反应方程式

HRID 658627 反应方程式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH:10][CH3:11])=[CH:5][CH:4]=1.Cl[S:13]([C:16]1[CH:25]=[CH:24][C:19]([C:20]([O:22]C)=[O:21])=[CH:18][CH:17]=1)(=[O:15])=[O:14]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][N:10]([CH3:11])[S:13]([C:16]2[CH:17]=[CH:18][C:19]([C:20]([OH:22])=[O:21])=[CH:24][CH:25]=2)(=[O:15])=[O:14])=[CH:5][CH:4]=1

参与物

3

反应物 2

HCID 485407N-(4-甲氧基苄基)-N-甲胺HCID 47383884-(氯磺酰基)苯甲酸甲酯

产物 1

HCID 252076194-(N-(4-methoxybenzyl)-N-methylsulfamoyl)benzoic acid

实验过程

Prepared as in example 5-27 from 1-(4-methoxyphenyl)-N-methylmethanamine and methyl 4-(chlorosulfonyl)-benzoate (Example 5-10c). MS (M−H, 335.1); 1H NMR (400 MHz, DMSO-d6): δ, ppm: 2.51 (s, 3H), 3.71 (s, 3H), 4.05 (s, 2H), 6.88 (d, 2H), 7.18 (d, 2H), 7.91 (d, 2H); 8.13 (d, 2H). Elemental analysis: (found): C, 57.47%, H, 4.77% and N, 4.31%; (theoretical): C, 57.30%, H, 5.11% and N, 4.18%

来源与证据

ORD记录
ord-7cd8bec4834b41d4b286b4258d56bee9
来源数据集
uspto-grants-2011_12
专利号
US08076491B2

关联笔记

加载中…