3-氯苯酐 → 3-氟酞酐

HRID 66950

反应方程式

HRID 66950 反应方程式
Cl[C:2]1[CH:12]=[CH:11][CH:10]=[C:4]2[C:5]([O:7][C:8](=[O:9])[C:3]=12)=[O:6].[F-:13].[K+]>>[F:13][C:2]1[CH:12]=[CH:11][CH:10]=[C:4]2[C:5]([O:7][C:8](=[O:9])[C:3]=12)=[O:6]

参与物

3

反应物 2

HCID 670143-氯苯酐HCID 522689氟化钾

产物 1

HCID 695513-氟酞酐收率 69%

反应条件

温度
235 °C

实验过程

A mixture of 20 parts of 3-chlorophthalic anhydride, and 20 parts of anhydrous potassium fluoride was heated and maintained at about 235° C. for about 9 hours. The reaction mixture was then cooled and the crude product removed by vaccum distillation and recrystallized from chloroform to yield 12.65 parts of purified 3-fluorophthalic anhydride (69% yield).

后处理

  1. temperaturewas heated
  2. temperatureThe reaction mixture was then cooled
  3. customthe crude product removed by vaccum distillation
  4. customrecrystallized from chloroform

来源与证据

ORD记录
ord-42b2a6f74dd5429695d292be7a7d85bf
来源数据集
uspto-grants-1982_08
专利号
US04343951

关联笔记

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