光气 → HCID 178484191，化合物

HRID 67785

反应方程式

HRID 67785 反应方程式
C(Cl)([Cl:3])=O.O1CCCC1.[CH3:10][NH:11][C:12]([NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=S>CN(C)C=O>[ClH:3].[CH3:10][NH:11][C:12]([Cl:3])=[N:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参与物

5

反应物 3

HCID 6371光气2 次HCID 8028四氢呋喃HCID 6982941-甲基-3-苯基硫脲

产物 1

HCID 178484191HCID 178484191，化合物

试剂、催化剂与溶剂 1

HCID 6228N,N-二甲基甲酰胺溶剂

实验过程

After passing 6.3 g of phosgene into 40 ml of absolute tetrahydrofuran at room temperature, 8 g of 1-methyl-3-phenylthiourea are added, with stirring, the color of the suspension changing instantaneously to yellow. After adding 0.5 ml of dimethylformamide, the mixture is stirred for 20 hours at room temperature, nitrogen is then passed through the reaction mixture for about 30 minutes, in order to drive off the phosgene, and the crystals are filtered off and washed with tetrahydrofuran. Crystals with a melting point of 169° C. (with decomposition).

后处理

  1. customat room temperature
  2. stirringthe mixture is stirred for 20 hours at room temperature
  3. filtrationthe crystals are filtered off
  4. washwashed with tetrahydrofuran

来源与证据

ORD记录
ord-0f79ccd029194271bff947b0b7abc7ea
来源数据集
uspto-grants-1982_08
专利号
US04346088

关联笔记

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