乙醚 → Ethyl dodecane hydroximate

HRID 67945

反应方程式

HRID 67945 反应方程式
[Cl-].O[NH3+].CC[O:6]CC.[CH2:9]([O:11][C:12](=[NH:24])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH3:10]>O>[C:12](=[N:24][OH:6])([O:11][CH2:9][CH3:10])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]

参与物

5

反应物 3

HCID 3283乙醚HCID 21645盐酸羟胺HCID 3442835Ethyldodecaneimidate

产物 1

HCID 86738559Ethyl dodecane hydroximate收率 77%

试剂、催化剂与溶剂 1

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

反应条件

温度
2 °C

实验过程

A mixture containing fourteen grams of hydroxylammonium chloride dissolved in 100 ml of water was added to 100 ml of ether in a 250 ml flask. The resulting mixture was cooled to 2° C. and 45.4 g of ethyldodecaneimidate were added to the mixture with stirring. The reaction mixture was stirred for an additional 30 minutes at 2° C. The layers were separated and the aqueous layer was extracted three times with 75 ml of ether. The ether layer and washings were combined and then dried over sodium sulfate and concentrated to yield 37.3 g (77% yield) of ethyl dodecane hydroximate as a white, solid substance. IR and NMR analyses confirmed the structure.

后处理

  1. stirringThe reaction mixture was stirred for an additional 30 minutes at 2° C
  2. customThe layers were separated
  3. extractionthe aqueous layer was extracted three times with 75 ml of ether
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated

来源与证据

ORD记录
ord-e15a47277379479ea60e7f0627918e63
来源数据集
uspto-grants-1982_08
专利号
US04347342

关联笔记

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