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(S)-quinuclidin-3-amine → (S)-N-[[[1-Azabicyclo[2.2.2]octan-3-yl]amino]carbonyl]-2-methoxybenzamide
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | (S)-quinuclidin-3-amine | HCID 719216 | — |
| 反应物 | Fumarate | HCID 5460307 | — |
| 反应物 | HCID 14119328 | HCID 14119328 | — |
| 产物 | (S)-N-[[[1-Azabicyclo[2.2.2]octan-3-yl]amino]carbonyl]-2-methoxybenzamide | HCID 15616384 | — |
反应步骤
The above compound was prepared, following the procedure of Example 1, from (S)-3-aminoquinuclidine (0.63 g, 5 mmol) and 2-methoxybenzoyl isocyanate (1.26 g, 7 mmol). The product (1.44 g) was converted to the 1:1 fumarate, mp 158°-159° C. (dec).
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US04983600 |
| 来源数据集 | uspto-grants-1991_01 |
| ORD ID | ord-ab525d72d9d84d2d88df5f621b72d01b |
| 来源说明 | uspto-grants-1991_01 |