氯甲酸异丁酯 → (R)-(2-adamantyl) 3-(isobutoxycarbonylamino)pyrrolidine-1-carboxylate

HRID 72131

反应方程式

HRID 72131 反应方程式
Cl.[NH2:2][C@@H:3]1[CH2:7][CH2:6][N:5]([C:8]([O:10][CH:11]2[CH:18]3[CH2:19][CH:14]4[CH2:15][CH:16]([CH2:20][CH:12]2[CH2:13]4)[CH2:17]3)=[O:9])[CH2:4]1.Cl[C:22]([O:24][CH2:25][CH:26]([CH3:28])[CH3:27])=[O:23]>>[CH2:25]([O:24][C:22]([NH:2][C@@H:3]1[CH2:7][CH2:6][N:5]([C:8]([O:10][CH:11]2[CH:12]3[CH2:13][CH:14]4[CH2:15][CH:16]([CH2:17][CH:18]2[CH2:19]4)[CH2:20]3)=[O:9])[CH2:4]1)=[O:23])[CH:26]([CH3:28])[CH3:27]

参与物

3

反应物 2

HCID 62365氯甲酸异丁酯HCID 67155574(R)-2-adamantyl 3-aminopyrrolidine-1-carboxylate HCl salt

产物 1

HCID 52942175(R)-(2-adamantyl) 3-(isobutoxycarbonylamino)pyrrolidine-1-carboxylate

实验过程

The title compound was prepared from (R)-2-adamantyl 3-aminopyrrolidine-1-carboxylate HCl salt and isobutyl chloroformate following a procedure analogous to that described in Example 3 Step 2. LC-MS Method 1 tR=2.1 min, m/z=365; 1H NMR (CDCl3) 0.97 (d, 6H), 1.58 (d, 2H), 1.70-2.05 (14H), 2.18 (m, 1H), 2.80 (1H), 3.29 (dd, 1H), 3.53 (m, 2H), 3.70 (m, 1H), 3.84 (m, 1H), 4.28 (1H), 4.80 (1H), 4.83 (s, 1H)

来源与证据

ORD记录
ord-cdf0962cd05a4fa2998e80064efa07cf
来源数据集
uspto-grants-2014_09
专利号
US08828985B2

关联笔记

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