硼氢化钠 → 4-Bromo-3-chloro-3,4,4-trifluorobutan-1-ol

HRID 726117

反应方程式

HRID 726117 反应方程式
[Br:1][C:2]([F:10])([F:9])[C:3]([Cl:8])([F:7])[CH2:4][CH:5]=[O:6].[BH4-].[Na+]>>[Br:1][C:2]([F:10])([F:9])[C:3]([Cl:8])([F:7])[CH2:4][CH2:5][OH:6]

参与物

3

反应物 2

HCID 4311764硼氢化钠HCID 218364804-Bromo-3-chloro-3,4,4-trifluorobutanal

产物 1

HCID 218364774-Bromo-3-chloro-3,4,4-trifluorobutan-1-ol

实验过程

Alternatively, the intermediate VII can be reduced with sodium borohydride without isolation to give 4-bromo-3-chloro-3,4,4-trifluorobutanol ((IX) in high yield; or by hydrolysis of 1,4-dibromo-2-chloro-1,1,2-trifluorobutane (XVI) to give IX. Oxidation of IX with Jones reagent to give VIII in 85% yield.

来源与证据

ORD记录
ord-3cfb632908184fea84e4d7cc5baa6404
来源数据集
uspto-grants-1998_01
专利号
US05708032

关联笔记

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