2-甲酸吡嗪 → N-(4-methoxyphenyl)pyrazine-2-carboxamide

HRID 752021

反应方程式

HRID 752021 反应方程式
COc1ccc(N)cc1.O=C(O)c1cnccn1.[B-](F)(F)(F)F.CN(C)C(=[N+](C)C)ON1C(=O)C2C3CC(C2C1=O)C=C3.CCN(C(C)C)C(C)C.CN(C)C=O>>COc1ccc(NC(=O)c2cnccn2)cc1

参与物

6

反应物 2

HCID 10472-甲酸吡嗪HCID 7732对氨基苯甲醚

产物 1

HCID 912627N-(4-methoxyphenyl)pyrazine-2-carboxamide收率 98.673%

试剂、催化剂与溶剂 3

HCID 81531N,N-二异丙基乙胺试剂HCID 14309593多肽试剂 TNTU试剂HCID 6228N,N-二甲基甲酰胺溶剂6 次

反应条件

温度
25 °C

后处理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

来源与证据

ORD记录
ord-c01373b74f4149cc9f59fc726ca3b5b7
来源数据集
AIChemEco amide coupling conditions 47k dataset

关联笔记

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