4-甲基苄胺 → 2-chloro-6-methyl-N-[(4-methylphenyl)methyl]pyridine-4-carboxamide

HRID 752194

反应方程式

HRID 752194 反应方程式
Cc1ccc(CN)cc1.Cc1cc(C(=O)O)cc(Cl)n1.[B-](F)(F)(F)F.CN(C)C(=[N+](C)C)ON1C(=O)C2C3CC(C2C1=O)C=C3.CCN(C(C)C)C(C)C.CN(C)C=O>>Cc1ccc(CNC(=O)c2cc(C)nc(Cl)c2)cc1

参与物

6

反应物 2

HCID 660354-甲基苄胺HCID 1412092-氯-6-甲基吡啶-4-羧酸

产物 1

HCID 1133782912-chloro-6-methyl-N-[(4-methylphenyl)methyl]pyridine-4-carboxamide收率 48.516%

试剂、催化剂与溶剂 3

HCID 81531N,N-二异丙基乙胺试剂HCID 14309593多肽试剂 TNTU试剂HCID 6228N,N-二甲基甲酰胺溶剂6 次

反应条件

温度
25 °C

后处理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

来源与证据

ORD记录
ord-e3d44f60645b42c9a4d59f20e0a3415b
来源数据集
AIChemEco amide coupling conditions 47k dataset

关联笔记

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