十二(烷)酸苄酯苯基酯 → 1,5-Di(benzylthiocarbamoylamino)naphthalene

HRID 758

反应方程式

HRID 758 反应方程式
[C:1]1([NH2:12])[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([NH2:11])[C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH2:13]([N:20]=[C:21]=[S:22])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(OCC)(=O)C>[CH2:13]([NH:20][C:21]([NH:12][C:1]1[C:10]2[C:5](=[C:6]([NH:11][C:21](=[S:22])[NH:20][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1)=[S:22])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参与物

4

反应物 2

HCID 2346十二(烷)酸苄酯苯基酯HCID 167201,5-萘二胺

产物 1

HCID 196932801,5-Di(benzylthiocarbamoylamino)naphthalene收率 30.7%

试剂、催化剂与溶剂 1

HCID 8857乙酸乙酯溶剂

反应条件

温度
80 °C

实验过程

1,5-Naphthalenediamine (0.791 g, 5 mM) was dissolved in 20 ml of ethyl acetate, and 2 equivalents of benzylisothiocyanate (1.492 g, 10 mM) were added. The mixture was stirred at 80° C. for 30 minutes. After cooling, the reaction mixture was filtered, and washed with ethylacetate/n-hexane to obtain 0.70 g (30.7% yield) of a colorless crystal of compound A-29.

后处理

  1. temperatureAfter cooling
  2. filtrationthe reaction mixture was filtered
  3. washwashed with ethylacetate/n-hexane

来源与证据

ORD记录
ord-d421bcbbd72f4cb18c2bcf8464545117
来源数据集
uspto-grants-1998_03
专利号
US05723075

关联笔记

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