碘化钠 → HCID 178418729，化合物

HRID 7618

反应方程式

HRID 7618 反应方程式
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([S:9][CH3:10])[N:3]=1.[NH2:11][C:12]1[CH:16]=[C:15]([CH3:17])[NH:14][N:13]=1.C(N(C(C)C)CC)(C)C.[I-].[Na+]>C(O)CCC>[Cl:8][C:6]1[N:5]=[C:4]([S:9][CH3:10])[N:3]=[C:2]([NH:11][C:12]2[NH:13][N:14]=[C:15]([CH3:17])[CH:16]=2)[CH:7]=1

参与物

6

反应物 4

HCID 5238碘化钠HCID 805314,6-二氯-2-甲基硫烷基嘧啶HCID 81531N,N-二异丙基乙胺HCID 931463-氨基-5-甲基吡唑

产物 1

HCID 178418729HCID 178418729，化合物

试剂、催化剂与溶剂 1

HCID 263丁醇溶剂

反应条件

温度
120 °C

实验过程

To a solution of 4,6-dichloro-2-methylsulfanyl-pyrimidine (5 g, 25.6 mmol) and 3-amino-5-methylpyrazole 2.61 g, 26.9 mmol) in BuOH (60 mL) is added diisopropylethylamine (4.69 mL, 26.9 mmol) followed by sodium iodide (3.84 g, 25.6 mmol). The reaction mixture is stirred for 15 hours at 120° C. The solvent is then removed in vacuo and the residue is purified by flash chromatography (SiO2, hexane/AcOEt gradient) to give [6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine.

后处理

  1. customThe solvent is then removed in vacuo
  2. customthe residue is purified by flash chromatography (SiO2, hexane/AcOEt gradient)

来源与证据

ORD记录
ord-b44cde9046554d3889ff52ec6590b1f4
来源数据集
uspto-grants-2006_08
专利号
US07087603B2

关联笔记

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