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7-氨基吲唑 → N2,N4-bis(7-indazolyl)-5-ethoxycarbonyl-2,4-pyrimidinediamine
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 7-氨基吲唑 | HCID 88901 | — |
| 反应物 | 2,4-二氯-5-嘧啶甲酸乙酯 | HCID 104020 | — |
| 产物 | N2,N4-bis(7-indazolyl)-5-ethoxycarbonyl-2,4-pyrimidinediamine | HCID 22060714 | — |
反应步骤
In like manner to N2,N4-bis(3-hydroxyphenyl)-5-ethoxycarbonyl-2,4-pyrimidinediamine, 2,4-dichloro-5-ethoxycarbonylpyrimidine and 7-aminoindazole were reacted to yield N2,N4-bis(7-indazolyl)-5-ethoxycarbonyl-2,4-pyrimidinediamine. 1H NMR (DMSO-d6): δ 8.70 (s, 1H), 7.54 (d, 2H J=8.4 Hz), 7.37 (m, 6H), 4.3 (q, 2H, J=7.0 Hz), 1.33 (3H, J=7 Hz); LCMS: ret. time 23.61 min.; purity: 94%; MS (m/e): 415 (MH+).
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US08835430B2 |
| 来源数据集 | uspto-grants-2014_09 |
| ORD ID | ord-6dd2908b30784f65af71e56de418d067 |
| 来源说明 | uspto-grants-2014_09 |