1,4-Dioxane hydrochloride → (R)-2-甲氧基-1-苯乙胺盐酸盐

HRID 773

反应方程式

HRID 773 反应方程式
[ClH:1].O1CCOCC1.C(OC([NH:15][C@@H:16]([CH2:23][O:24][CH3:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O)(C)(C)C>>[ClH:1].[CH3:25][O:24][CH2:23][C@H:16]([NH2:15])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参与物

3

反应物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 54257308N-t-butoxycarbonyl-(R)-alpha-methoxymethylbenzylamine

产物 1

HCID 66589172(R)-2-甲氧基-1-苯乙胺盐酸盐

实验过程

60 ml of 4N-HCl/dioxane solution was added to 4.02 g (16.0 mmols) of N-t-butoxycarbonyl-(R)-α-methoxymethylbenzylamine, and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure. 30 ml of ether were added to the residue, and this was further concentrated to obtain (R)-α-methoxymethylbenzylamine hydrochloride in quantitative yield.

后处理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. addition30 ml of ether were added to the residue
  3. concentrationthis was further concentrated

来源与证据

ORD记录
ord-3d062dc2d8ab4e1391656e4f536498a8
来源数据集
uspto-grants-1998_03
专利号
US05723165

关联笔记

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