1,4-Dioxane hydrochloride → (1R)-2-ethoxy-1-phenylethan-1-amine hydrochloride

HRID 775

反应方程式

HRID 775 反应方程式
[ClH:1].O1CCOCC1.C(OC([NH:15][C@@H:16]([CH2:23][O:24][CH2:25][CH3:26])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O)(C)(C)C>>[ClH:1].[CH2:25]([O:24][CH2:23][C@H:16]([NH2:15])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH3:26]

参与物

3

反应物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 53739234N-t-butoxycarbonyl-(R)-alpha-ethoxymethylbenzylamine

产物 1

HCID 70183214(1R)-2-ethoxy-1-phenylethan-1-amine hydrochloride

实验过程

12.5 ml of 4N-HCl/dioxane solution were added to 0.66 g (2.5 mmols) of N-t-butoxycarbonyl-(R)-α-ethoxymethylbenzylamine, and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure, 30 ml of ether was added to the residue, and this was further concentrated to obtain (R)-α-ethoxymethylbenzylamine hydrochloride at a quantitative yield.

后处理

  1. concentrationThe reaction mixture was concentrated under reduced pressure, 30 ml of ether
  2. additionwas added to the residue
  3. concentrationthis was further concentrated

来源与证据

ORD记录
ord-ae03dc6af35144969588f144b56bba80
来源数据集
uspto-grants-1998_03
专利号
US05723165

关联笔记

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