2,4-二甲氧基苯甲酸 → 2,4-二甲氧基苯甲酰氯

HRID 78466

反应方程式

HRID 78466 反应方程式
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=[O:6].O=S(Cl)[Cl:16]>>[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:4]=1[C:5]([Cl:16])=[O:6]

参与物

3

反应物 2

HCID 70522,4-二甲氧基苯甲酸HCID 24386氯化亚砜

产物 1

HCID 27347192,4-二甲氧基苯甲酰氯

实验过程

A solution of 2,4-dimethoxybenzoic acid (0.25 g, 1.4 mmol) in 5 mL of SOCl2 was warmed to reflux and was allowed to stir for 2 hours. The mixture was cooled to ambient temperature and concentrated under reduced pressure. The crude material was diluted with 5 mL of toluene and concentrated under reduced pressure. This dilution with toluene and concentration was repeated two additional times to give the crude title compound which was used without additional purification or characterization.

后处理

  1. temperatureto reflux
  2. concentrationconcentrated under reduced pressure
  3. additionThe crude material was diluted with 5 mL of toluene
  4. concentrationconcentrated under reduced pressure
  5. concentrationThis dilution with toluene and concentration

来源与证据

ORD记录
ord-bd29039174134ba49dfadb7c87cf493a
来源数据集
uspto-grants-2014_09
专利号
US08841334B2

关联笔记

加载中…