六水硝酸铽 → 6-Acetylamino-2-methyl-3-nitro-benzoic acid

HRID 805

反应方程式

HRID 805 反应方程式
[N+:1]([O-:4])(O)=[O:2].[CH3:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][C:16](=[O:18])[CH3:17])[C:7]=1[C:8]([OH:10])=[O:9]>O>[CH3:5][C:6]1[C:14]([N+:1]([O-:4])=[O:2])=[CH:13][CH:12]=[C:11]([NH:15][C:16](=[O:18])[CH3:17])[C:7]=1[C:8]([OH:10])=[O:9]

参与物

4

反应物 2

HCID 944六水硝酸铽HCID 28014002-Acetamido-6-methylbenzoic acid

产物 1

HCID 152831716-Acetylamino-2-methyl-3-nitro-benzoic acid

试剂、催化剂与溶剂 1

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

反应条件

温度
10 °C

实验过程

271 ml of 98% nitric acid are initially taken at -5° C. and 106 g (0.55 mol) of the 2-methyl-6-acetamidobenzoic acid prepared in 1. are added in portions. After stirring at 10° C. for one hour, the reaction mixture is poured into a mixture of 540 g of ice and 270 ml of water. The deposited precipitate is filtered off with suction, washed with water and dried under reduced pressure at 50° C.

后处理

  1. customare initially taken at -5° C.
  2. additionare added in portions
  3. filtrationThe deposited precipitate is filtered off with suction
  4. washwashed with water
  5. customdried under reduced pressure at 50° C.

来源与证据

ORD记录
ord-036dc1bd98f447088e22557193b51876
来源数据集
uspto-grants-1998_03
专利号
US05723415

关联笔记

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